CHAI is a Biological Operating System for practices advancing healthspan.

See what’s changing, what needs attention, and what to do next—between visits.

One place for patients to log meals, confirm doses, ask CHAI, and message your practice. Each patient’s labs, protocols, wearable data and symptoms connect in one record, so you see the trends and priorities behind your next decision.

Request a practice demo Take the CHAI tour Patients join through their clinic. Watch the film (2½ min)

CHAI in practice. The founder’s own health record.

Ask a question. See the patient data behind the answer. CHAI connects labs, protocols, symptoms and wearable data, with the supporting results shown alongside its response.

Recorded CHAI response · Synthetic patient

Reading Michael’s record

Abbreviated from the recorded answer

Across Michael's last three draws (2025-09-02, 2026-03-17, 2026-08-28), the lipid, glucose, liver and inflammation markers all rose steadily while the sex hormones all fell.

ApoB 118 → 125 → 132 mg/dL; triglycerides 218 → 238 → 252 mg/dL
HbA1c 5.8 → 6.1 → 6.3%, inside the prediabetes range
ALT 52 → 58 → 64 U/L; hs-CRP 2.8 → 3.4 → 3.9 mg/L
Total testosterone 348 → 312 → 298 ng/dL

Checks it suggests before the next draw: iron studies with ferritin, a CBC so FIB-4 can be calculated, LH, FSH and prolactin, TSH, a urine albumin-to-creatinine ratio, and Lp(a) if it has never been measured. It closes by saying a clinician should review these results before the next scheduled draw.

Across Michael's last three draws (2025-09-02, 2026-03-17, 2026-08-28), the lipid, glucose, liver, and inflammation markers all rose steadily while the sex hormones all fell.

No marker in these clusters reversed direction. The only mixed signals are HDL, which moved from 35 to 33 to 34 mg/dL, and Vitamin D, which moved from 24 to 22 to 26 ng/mL. Both stayed out of range.

Date	LDL (mg/dL)	ApoB (mg/dL)	Non-HDL (mg/dL)	Triglycerides (mg/dL)	HDL (mg/dL)
2025-09-02	154	118	197	218	35
2026-03-17	162	125	208	238	33
2026-08-28	168	132	211	252	34

Triglycerides kept climbing even though Michael takes 2 g of fish oil daily. The latest triglyceride-to-HDL ratio is about 7.4 (252 / 34), which usually goes along with insulin resistance.

Date	Glucose (mg/dL)	HbA1c (%)	Insulin (µIU/mL)	ALT (U/L)	AST (U/L)	hs-CRP (mg/L)
2025-09-02	104	5.8	14.2	52	34	2.8
2026-03-17	108	6.1	17.8	58	38	3.4
2026-08-28	112	6.3	19.5	64	42	3.9

HbA1c is now 6.3%. That is inside the prediabetes range and 0.2 points below the diabetes cutoff of 6.5%. The fasting glucose and insulin values give an estimated HOMA-IR of about 3.6, then 4.7, then 5.4. GGT was only measured twice, but it also rose, from 62 to 71 U/L. Rising ALT, AST, and GGT together with insulin resistance fit a fatty-liver pattern, but these labs can't confirm it.

Date	Total T (ng/dL)	Free T (pg/mL)	SHBG (nmol/L)	Estradiol (pg/mL)
2025-09-02	348	7.2	48	28
2026-03-17	312	6.4	42	22
2026-08-28	298	5.8	38	18

LH (3.2 mIU/mL) and FSH (2.8 mIU/mL) were only measured on 2026-03-17. Both are in the low-normal range, which leans toward a secondary (pituitary-side) cause of the falling testosterone rather than a testicular one. However, it's a single draw. The drop in SHBG matches the rising insulin, because insulin resistance lowers SHBG.

Some findings from outside the last three draws are also relevant:

eGFR fell from 92 to 86 mL/min/1.73m2, and creatinine rose from 1.0 to 1.1 mg/dL (2025-02-07 to 2026-08-28).
Ferritin was 298 ng/mL on 2025-09-02 and hasn't been rechecked.
TSH was last measured on 2025-09-02 at 2.4 mIU/L.
Current diastolic blood pressure is 90.18 mmHg.

Checks for the next draw so results are comparable and the gaps get filled:

Keep the same conditions: fasting for 10–12 hours, a 7–10 am draw for testosterone, and no hard training or alcohol for 48 hours beforehand.
Recheck ferritin and add iron, TIBC, and transferrin saturation. High ferritin alongside rising liver enzymes needs an iron-overload screen, and ferritin can also rise with inflammation.
Add a CBC with platelets so FIB-4 can be calculated, and consider a liver ultrasound or FibroScan.
Repeat LH and FSH, and add prolactin, to follow up on the falling total and free testosterone.
Repeat TSH, since the last value is a year old and thyroid function affects both lipids and testosterone.
Add a urine albumin-to-creatinine ratio, given the eGFR decline and the diastolic blood pressure of 90.
If Lp(a) has never been measured, add it once, since ApoB is at 132 mg/dL.
Look beyond the labs as well: alcohol intake, any new medications or supplements, weight trend (only the current 196.62 lb is on file), and sleep apnea screening, which is linked to both low testosterone and metabolic decline.
Confirm Michael is actually taking the Vitamin D3 2000 IU. Levels are still low at 26 ng/mL, so ask the clinician whether the dose should change.

There are no clinical notes on file, so these results can't be linked to any change in diet, activity, or medication. With HbA1c close to the diabetes threshold and ApoB still rising, a clinician should review these results before the next scheduled draw.

A pattern for the clinician to review, not a diagnosis.

Daily care starts on Today.

Patients can log a meal, confirm a dose, ask CHAI, or message the practice while their dashboard updates in the background.

Behind it, CHAI connects each patient’s labs, protocol, wearable data and symptoms across time, in one record that updates every morning, so you can see how lab results, protocol changes and daily patterns relate.

CHAI’s Today screen on a phone, in the morning: a ring with the calories left today, protein and steps against their floors, the morning doses as tap cards, the one thing to do, today’s entries as rows, and a pill reading Dashboard ready — Today, first thing: calories left, protein and steps against their floors, doses to confirm, and the one thing.

The patient's data

LabsLab history across providers.
DosesScheduled doses and patient confirmations.
WearablesSleep, HRV and heart rate.
SymptomsIn the patient's own words.
Check-inHow the morning feels.

CHAI connects it

Reads everything together, every morning.

Daily guidance

The daily briefingWhat changed, and why.
Ask CHAIAnswers grounded in their data.
The next requisitionWhat's missing, with pricing.
Training and sleepInformed by labs and recovery data.

Your clinical teamReviews the findings. Directs the care.

Connect the data your patients already useLab PDF importQuest ordering codesAt-home panelsApple HealthApple WatchOura and Whoop, via Apple Health

The daily story · patients on a GLP-1

Sarah’s appetite changed. Her care team needs the full picture.

Sarah, 45, takes semaglutide and hormone therapy. She logs meals by text or photo on Today, and can correct a meal from its entry. CHAI brings her estimated intake together with her weight trend, activity and symptoms, so her care team sees what needs a closer look between visits. On a GLP-1, adequate nutrition stays in view.

Synthetic patient. Real CHAI workflow. CHAI’s own words.

Sarah’s Today screen after lunch: the meal she logged by text, its row open with the items and CHAI’s estimate, today’s totals against the calorie ceiling and the protein floor — Her Today screen after lunch. A photo of the plate works the same way, and “it was two fillets” corrects the same meal.

Today’s log for Sarah Mitchell: meals 541 of 1,680 kcal, protein 35 of 125 g, with CHAI AI’s three lines: protein 35 g against a 125 g floor; 540 kcal logged, under the 1,250 floor, third day running, days this low put lean mass at risk; nausea logged 2 of the last 3 days, has it affected how much she can drink, her care team should hear about persistent nausea — 1The floors, after every mealToday’s log carries CHAI AI’s read: protein 35 g against a 125 g floor, and 540 kcal logged, under the 1,250 floor for the third day running, with the question of whether the log is complete. Repeatedly low intake puts lean mass at risk; her care team can look at nutrition and training with her.View full screen

Sarah’s Fitness tab on her phone, Sunday Sep 27: In 108 of 1,680 kcal, 1 meal; Burn (est.) 1,926 kcal, Apple Health estimate, rest day; Left today 1,572 kcal; Protein 16 of 125 g, floor 125 g, set by the care team; Weight 137.1 lb, 12.1 to go to 125; Today, rest. CHAI AI, noon: Protein 16 g so far; the day needs 125. The next meal is the moment, aim for about 54 g there. — 2Fuel and training on one tabIn, out, what is left, protein against her floor, weight to goal, today’s session, and CHAI AI’s line for the day, which brings logged intake, hydration, symptoms and activity into the same read. Every meal she logs lands in the Fuel card underneath.View full screen

CHAI’s evening line on Sarah’s Today at 8:35 pm: 650 of 1,680 kcal so far, protein 46 of 125 g; 650 kcal logged, under the 1,250 floor, third day running; nausea logged 2 of the last 3 days, has it affected how much she can drink, keep fluids going through the day, and her care team should hear about persistent nausea or trouble keeping fluids down — 3When the symptoms show up, so does the concernSarah logged nausea on two of the last three days. That evening CHAI’s line on her Today asks whether it has affected how much she can drink, asks her to keep fluids going, and says her care team should hear about persistent nausea or trouble keeping fluids down.View full screen

Ask CHAI: Is Sarah eating enough on semaglutide? What should we change this week? The recorded answer: going by her logs, no; she averaged 476 kcal and 34 g of protein a day for 7 days, far under her floors of 1,252 kcal and 125 g. But her weight hasn’t moved, so the logs and the scale disagree. Three plausible explanations, and the data can’t tell them apart yet: she isn’t logging everything; she really is eating very little; some of each. The nausea is not in doubt. — 4Is she eating enough?A clinician asks. CHAI AI says the logs and the scale disagree, lays out the plausible explanations the data cannot yet tell apart, treats fluids as a concern to raise with her rather than a finding, and notes that the nausea is not in doubt. Any dose change is for her prescriber to consider.View full screen

Clinician dashboard card for Sarah Mitchell, 45, Perimenopause Hormonal Optimization week 6 of 52: Needs you. Nausea or vomiting logged 3 of the last 7 days on a GLP-1, fluids logged 0.7 L a day; ApoB, DHEA-S, SHBG and homocysteine findings; bio age 36.2; blood pressure 7-day mean 118 systolic against a 120/80 target; Nutrition, last 7 completed days (logged intake): avg 537 kcal on 6 logged days, protein 38 g of 125, 6 under the protein floor, 6 under the calorie floor (GLP-1); active today — 5The practice sees the numbersMonday’s dashboard puts her under “Needs you”: nausea or vomiting logged three of the last seven days on a GLP-1 with fluids logged at 0.7 L a day, and six completed days logged under the protein and calorie floors (today’s partial log excluded), beside her labs and recovery signals. The dashboard shows totals; her meal photos are visible only to her.View full screen

CHAI proposes. The dose stays where it is until a clinician or practice-admin account accepts a change. CHAI records which account accepted it and when. Which roles may prescribe is the practice’s own setting; CHAI checks the account role, not prescriber authority. Follow Sarah in the CHAI tour → See this workflow for your practice → Interested in CHAI for yourself? Join the interest list →

From identifying a trend to planning the next step.

Michael, 43. No active protocol. Three consecutive lab draws show a worsening pattern.

Follow his case through CHAI—from the clinician’s dashboard to the next lab order.

Synthetic patient. Real CHAI workflow.

Clinician dashboard card for Michael Chen, 43, no active protocol: Needs you. ApoB 132 vs target 90, ALT 64, HbA1c 6.3% and hs-CRP 3.9, each three draws in a row; the next requisition adds Lp(a), and a coronary calcium (CAC) scan is listed to schedule — 1Identify the priorityMonday's dashboard puts him under “Needs you”: ApoB, ALT, HbA1c and hs-CRP above target, three draws in a row.View full screen

ApoB marker sheet: 132 mg/dL, above range. Trend basis: fitted within LabCorp only (2 points), 1 other-lab point shown, not fitted. 118 to 132 mg/dL over the last 3 draws — 2Trace the trendApoB 118 → 125 → 132 mg/dL across three draws. The fitted trend uses the two LabCorp draws; the earlier Quest draw is shown, not fitted.View full screen

Ask CHAI on Michael's labs: across his last three draws the lipid, glucose, liver and inflammation markers rose while the sex hormones fell, with the lipid table by draw — 3Connect the findingsAsk CHAI lays the three draws side by side, and lists what to check before the next one.View full screen

Requisition lines: Cystatin C with eGFR, added by rules A02 and R13, never resulted; C-reactive protein, added by R28 and F01, last measured 34 days ago via LabCorp — 4Prepare the next drawReview a draft lab order with the reason for each test, relevant flags and itemized pricing.View full screen

Your team reviews the next step. CHAI prepares proposed changes for review. An authorized clinician or practice administrator must accept them before they are applied. Follow Michael in the CHAI tour →

One question. The patient’s connected history.

Every lab, dose, wearable reading and symptom sits in one record, so one question reaches across all of it. CHAI computes the statistics itself, shows the draws it used, and says what the data can't answer.

Finds the markers you namein their own history, over the window you ask
Calculates the statisticsSample size, time span, trends and correlations
Shows the data it usedcheckable in seconds
Lines each change up with the protocolby date, for you to judge
Makes gaps visibleMissing results, limited samples and assay limits

Ask CHAI answer: six markers worsened in the last 90 days against the June baseline, with a table of three draws and the target for each — What worsened in 90 days · each marker against its target

Ask CHAI answer: the statin holds lipids below 2022–2024 levels but ApoB rose 27% since the cycle began; a table of three lipid panels — Three lipid panels · the statin and the cycle, side by side

Ask CHAI answer: when total testosterone is above 1,000 ng/dL, hematocrit sits between 48% and 52.6%; a table of draws with total T and hematocrit — Testosterone vs hematocrit · 15 draws paired by date

For your practice

See the pattern across visits. Know which patients need a closer look.

A marker rising across three draws. An incomplete lab checkpoint. An unconfirmed dose. CHAI brings the finding and its context into view before the visit.

Calculations you can inspect.

requisitiondose changesstatisticsverdict

CHAI shows the calculation, the explanation and the results behind it.

Every result keeps its lab and method.

QuestLabCorpat-home panels

A trend is fitted within one lab.

A clear record for each patient.

patientsinvitespatient context kept

Each answer is tied to the patient it was asked about.

Your week’s patient priorities, in one view.

See which patients need review and the findings behind each priority. A one-page summary arrives by email every Monday.

Who needs you, and whythe finding and the number behind it
Doses takenagainst what was scheduled
HRV, resting HR and sleep7 days against 30
What the next requisition addsper patient

Weekly practice report for Dr. Elena Vasquez, week of September 21, 2026: 4 patients, 94% of scheduled doses taken, 2 medications run out; each patient with findings, doses taken, HRV, resting heart rate and sleep over 7 days against 30, what the next requisition adds and any scan to schedule

The Monday reportone page for the whole practice · open it

CHAI · Clinician dashboard

Clinician dashboard for a synthetic practice: 4 patients, 4 need you this week, 94% of scheduled doses taken, 2 medications run out; a card per patient with findings, bio age, doses, HRV, resting heart rate, sleep, what the next requisition adds and any scan to schedule

Keep care connected between visits.

Quiet between visits

TodayContact at the draw and the visit

With CHAIA daily check-in, and a follow-up when skipped

Know what’s been confirmed

TodayUnconfirmed doses require follow-up.

With CHAIPatients confirm doses with a tap on Today.

Keep refills connected to your practice

TodayReordered wherever is fastest

With CHAIDays covered. Refills route to you.

Wearables unused

TodayThe watch knows. The chart doesn't.

With CHAIWearable trends inform recovery and training reviews.

Keep patients engaged

TodayNo visible progress

With CHAIBiological-age trends, body-system insights and a daily briefing.

A consistent workflow for ongoing care.

Intakeinvite · import their lab PDFs
Requisitionwhat to draw, why, priced
Reviewrisk per compound · every rule checked
Amenddose changes proposed · clinician or admin accepts
Reportprintable: protocol, labs, reads

See CHAI in action in 30 minutes.

Request a practice demo Take the CHAI tour

For your patients

Your practice, in their pocket. Every morning.

Give patients a daily briefing, a simple check-in and follow-up that reflects their care plan.

The morning check-in

What synced, what didn't, and how the morning feels.

Captured overnightsleep, HRV, heart rate, weight, from Apple Health
Only what didn't sync is askedblood pressure, SpO₂, temperature
How's this morning?one tap, or a sentence
A quick signal, if they wantthe questions follow the patient
Skip it and CHAI follows uponce, on Today

Follow-up, in the app

It asks, backs off, and stays quiet when there's nothing to say.

It asksunlogged is "unconfirmed", not "missed"

Backs off, never gives uptwo misses and it widens to weekly

A sentence is enough"all except Thursday's" is understood

Knows the calendardraw prep, "drawn?", "results?"

Reads their wearablesa stale watch gets one line

Quiet when there's nothingNo routine nudge when nothing is outstanding.

Morning check-in: sleep 7.62 h, deep sleep 1.08 h, REM 1.71 h, HRV 38.4 ms, resting heart rate 61 bpm and weight 182.4 lbs, each marked synced from Apple Health with its change against baseline; blood pressure, SpO2 and body temperature offered for manual entry; how's-this-morning chips and a free-text box — **Morning · The check-in**What synced, and how it feels.

Today at 10:02 on the sample member's phone: the morning read card at the top of the day, with where they are, CHAI AI's line, the signals that moved and what is due — **10:00 · The morning read**Every morning, on Today.

Today at 12:05: the noon check card, two morning doses still unconfirmed, the check-in question, protein so far against the floor — **12:00 · Midday check**While the morning is still fresh.

Today at 7:20 pm: the evening check card, four doses unconfirmed, a watch that has not synced in four days — **7:15 pm · Daily check**Only when something is outstanding.

Are you a patient? Bring CHAI to your clinic →

Connected intelligence for the care you provide.

GLP-1 and weight carenutrition, symptoms and progress between visits Metabolic and cardiovascularApoB, HbA1c, liver, hs-CRP Hormone therapyTRT and HRT, with checkpoints and review Women’s healthperimenopause, read for her Sexual wellnessa daily vital sign Fitness and sleepfuel, training and recovery, read together Blood pressurethe cuff, the dose, and what changed Hematocrit on testosteronea ceiling, a tier, and the draw that decides Labs from more than one sourceone marker, two labs, one honest trend Protocol cyclescheckpoints, supply and an AI review Seasons and arcsweeks with a purpose, on the way to a date For practice managerssupply, refills and the Monday report

In the patient's pocket.

Today on a phone: a member’s message to the practice and the clinician’s reply, with the clinician’s name, in the day’s list — The practice conversationMessage the practice from the same box.The reply appears in the day with the clinician’s name.

CHAI morning brief with today's read, vitals tiles and the lab read — The daily briefingWhat changed since yesterday, and the one thing to do today.Apple Health, doses and symptoms, read together.

Biological age card with likely range, engine and PhenoAge values and the Built-from breakdown — Biological ageThe Centurion Clock, blended with PhenoAge.A system-by-system view of biological age, with its range and the factors behind it.likely 45.8–47.8 · engine 45.4 · PhenoAge 51.0

Body map with thirteen systems, each carrying one measure — Body mapThirteen body systems. A clearer view of each.See a system-age estimate or relevant marker for each body system, with missing data clearly identified.

Requisition with package and à-la-carte lines and the CHAI AI review — LabsThe next lab order, with the gaps identified.CHAI adds missing markers to a draft lab order for your team to review.10 tests · $880.50 · 2 markers added

Getting started

We set up your practice. And every patient in it.

Hands-on onboarding for your practice and patients. Our team handles setup and guides each patient, or trains your staff to do it.

Practice setupWe set up and run your practice’s own CHAI server. You tell us which patients start first.
Patient introductionEach patient receives a personal login and guided setup from our team or your trained staff.
Records and protocolWe import their lab PDFs and current protocol, and check each result arrives with its lab and date.
Their iPhoneWe guide patients through CHAI, secure access and Apple Health sharing on their iPhone. Daily messages arrive in the app.
The first morning readOnce their data syncs: what changed, the one thing to do today, and the morning check-in.
Support that staysWe support patients and staff by email. Clinical questions stay with your clinicians.

What CHAI doesruns your server, imports records and protocols, trains your staff, supports patients

What your practice doeschooses patients, introduces CHAI, keeps clinical decisions

What the patient doesinstalls CHAI, sets up secure access, connects Apple Health

Patients need an iPhone with Apple Health; Android isn’t supported yet. The CHAI app is free and will be distributed through the App Store. CHAI runs alongside your EHR, not instead of it.

Private by design. Built to the HIPAA Security Rule.

Private networknot open to the internet

Encryptedin transit and at rest

Never soldnever used to train a model

Every change on recordan append-only log

Your team decidesdose changes wait for a clinician or practice admin to accept them

Their own conversationoutreach and clinician replies stay inside CHAI

Approvals: CHAI proposes dose and protocol changes. Only a clinician or practice-admin account can accept one, nothing is applied until they do, and each acceptance is logged with who and when. A signed clinician review record is in development. How CHAI handles data →

Questions practices ask.

Is CHAI available now?

Practice demonstrations are available now. CHAI runs daily on its founder’s record, and we’re preparing our first practice deployments.

Does it replace our EHR?

No. CHAI runs alongside it and holds the longitudinal record: labs, protocol, wearables and symptoms. There's no direct EHR connection yet; CHAI's patient reports print for the chart.

What gets imported, and how?

Lab results arrive as PDFs from any lab, and each result keeps its lab and method. Wearable data comes through Apple Health. Doses are confirmed by the patient on Today. Quest ordering codes are built into the requisition; reading Quest's own result files directly is in development.

Which devices do patients need?

An iPhone with Apple Health, the free CHAI app (to be distributed through the App Store) and a private-network app we set up with them. Apple Watch works directly, and Oura and Whoop work through Apple Health. Android isn’t supported yet. CHAI also runs in a browser on a desktop or iPad.

Where do CHAI's messages arrive?

On Today, inside the CHAI app.

Can patients message our practice?

Patients can send a message from Today. Your team replies from the clinic page's Inbox, and the reply appears in the patient's conversation.

Who does the setup, and how long does it take?

We set up your practice’s server, import patient records and train your team. Patients receive guided onboarding from us or your trained staff. We’ll agree on a rollout schedule based on your starting group.

What happens with a critical value?

CHAI has hard safety rules for critical values, such as systolic blood pressure of 180 or higher, a resting heart rate of 120 or higher, severe kidney impairment, and hematocrit of 54% or higher. They override everything else it says. CHAI isn't an emergency service: urgent findings follow your practice's own process.

Who approves changes?

CHAI proposes dose and protocol changes, with the calculation behind each one. Only a clinician or practice-admin account can accept one; nothing is applied until they do, and each acceptance is logged with who accepted it and when. A signed clinician review record is in development.

How is it priced?

Pricing is based on the number of patients using CHAI in your practice. We’ll outline pricing for your planned rollout during the demo.

I've managed my own health for most of my life. No one ever had the whole picture, so I built something that does.

— Barry Katzman, founder of CHAI

CHAI reads my whole record every morning, finds the trends and the correlations, and tells me what to do next, with the data behind it. Anything that needs my clinician goes to my clinician, and my clinician sees all of it.

Read Barry's story →

Request a practice demo.

In 30 minutes, follow a patient from the first flagged trend to the next lab order, explore Ask CHAI, and discuss a rollout for your practice.

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